Breast tissue characterization with high-frequency scanning acoustic microscopy.
R. E. Kumon, I. Bruno, B. Heartwell, and E. Maeva (Dept. of Phys., Univ. of Windsor, 401 Sunset Ave., Windsor, ON N9B 3P4, Canada).
We have performed imaging of breast tissue using scanning acoustic microscopy (SAM) in the range of 2550 MHz with the goal of accurately and rapidly determining the structure and composition throughout the volume of the samples. In contrast to traditional histological slides, SAM images can be obtained without special preparation, sometimes even without sectioning, but with sufficiently high spatial resolution to give information comparable to surface optical images. As a result, the use of high-frequency SAM at the time of breast lumpectomy to identify disease-free margins has the potential to reduce reoperative rates, patient anxiety, and local recurrence. However, only limited work has been performed to characterize breast tissue in the frequency range above clinical ultrasound devices. The samples are 4-cm2-thick sections (23 mm) taken from mastectomies and preserved in formalin. They are placed between two plates and immersed in water during imaging. Attenuation images are acquired by focusing the acoustic beam at the top and bottom of the samples, although better results were obtained for bottom focusing. For purposes of comparison and identification of histological features, acoustical images will be presented along with optical images obtained from the same samples. [Work supported by CIHR.]
Technical Area: Biomedical Ultrasound/Bioresponse to Vibration (High-Frequency Imaging)
(PACS) Subject Classification number(s): 43.80.Jz